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You can run each of your 50 IDF files with each of the 50 weather files (2500 total simulations) by using EP-Launch itself. Just go to the Group Input Files tab and press the New Group button. You will select the 50 IDF files on the first screen (you may have to change the path of the files by pressing the path button) then on the next screen select the 50 weather files. Using the Toggle All button is the easiest way to select a large number of files. On the fourth screen you need to select "User Defined Location" and change the location to use a file name that contains the IDF and weather file names (%H\%I_%W) or separate directories for each weather file (%H\%W\%I). Save the group file on the next step and you may want to edit it to make sure it how you want. Then it is as simple as pressing Simulate Group.

I would probably test this approach using three IDF files and three weather files to make sure it is how you want it before you commit to that many simulations.

You might want to review the documentation on EP-Launch.