Should infiltration air be removed?

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Hi All,

I'm using EnergyPlus to model a zone that is being supplied with conditioned air and has infiltration (ZoneInfiltration:DesignFlowRate). I see that the flow rates for my HVAC equipment balances (e.g. HVAC air flow supply = HVAC return air flow). 1)Shouldn't the system also remove the additional air introduced via infiltration? 2) If it doesn't, does the "build of up air" skew the results (e.g. increasing the total volume of air to heat/cool in the zone)?

Thanks!