Can real interior and exterior temperature/humidity improve E+ model?

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The traditional way to use this measured data is to compare it to simulated data and then calibrate selected model inputs to minimize differences between these streams. This is an iterative compute-intensive process, but there are several packages that will do this for you automatically. Perhaps more interestingly, the next version of EnergyPlus (due out at the end of the month) has a new research feature called "HybridModel" where a selectively inverted heat-balance equation actually takes the zone temperature stream as input and uses it to calculate infiltration and internal thermal mass directly. This partially calibrated model can then be used as the starting point for a more traditional calibration process.