This may sound a little old-fashioned, but it's worked for me for over 30 years in doing zillions of parametric simulations by adding macros to a template input file, and then creating a master batch file that calls an individual batch file like runeplus.bat once for each run. What are macros? That's an interpreter language first developed for DOE-2 back in the mid-80's, and then made into a stand-alone program for EnergyPlus called EPMacro. I still have my first version of the DOE Reference Buildings done in 2006 and all using macros, but DOE didn't like that and requested flat IDF files.
To show how macros work, I was going to provide a link to a sample file and batch scripts in EnergyPlus, but then decided just to give a link to the entire DOE Commercial Buildings analysis package that I put together in 2007 here. There are two versions, one done for EnergyPlus and the other for DOE-2.1E. The EPlus version zip file had included the EnergyPlus (V3.0 ?) and EPMacro executables, but I deleted those to avoid setting off download warnings.
Using E+ (with or without a GUI?)? Do you have experience in any programming language or interest in learning one?
Do you have to modify the .idf files parametrically before you run the simulations?
This may sound a little old-fashioned.... I moved this comment to an answer to overcome the character limit, as well as to attach a link .
@Jim Dirkes I believe you are chairing a session at the ASHRAE Energy Modeling Conference next week where Peter Ellis will give a talk on "Parametric Modeling with Templates and Scripting". Peter will present on something that targets exactly this kind of application. Full disclosure: I work with Peter on this project.
Thanks for highlighting this, Neal. I was focused on "Chair" duties, not the presentation content and didn't make that connection. I am now looking forward to it even more.