Central Cooling Design Supply Air Temperature in Sizing:System

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To be precise, yes, it’s not the case for blow-through. Also, “the temperature at the setpoint node in whatever SetPointManager is specified for the system” is not precise. Sizing:System always takes draw-through fan heat into account even if there is no SetpointManager:MixedAir object. The more precise description would be “the temperature at the Supply Side Outlet Node of the AirLoopHVAC”.

That sounds right. So, answering your question, the Central Cooling Design Supply Air Temperature in Sizing:System is the design supply air temperature at the Supply Side Outlet Node of the AirLoopHVAC. Perhaps the documentation should be updated to reflect that.

@ericmartinpe describes the correct definition. The temperature at the supply side outlet node, which is the same as the demand side inlet node or the temperature entering the zone or zone terminal unit, if used. This value is not used in zone sizing (where the Sizing:Zone input is used) but is used for system and terminal unit sizing.