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To interact with E+ during runtime you can use either plugin or library API - here is the starting point: https://bigladdersoftware.com/epx/docs/23-1/input-output-reference/group-python-plugins.html

There are some python libraries designed to modify idf file - https://pypi.org/project/eppy/ , https://github.com/rbuffat/pyidf However, I don't have much experience with these projects. I modify the idf file using simple regex find & replace.