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OpenStudio doesn't let you do this because that is a constraint in EnergyPlus. The most common solution for this would be to provide ventilation through an air loop and conditioning through zone equipment.

There is actually an old old video on YouTube that demonstrates this with a packaged terminal heat pump as zone equipment, but I think without the energy recovery.

Another technique I have heard of in different use cases when someone wants to model two air loops in one zone, is to model it as two zones with zone mixing objects between the zones. I don't have any experience doing that to know how well it works.