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Hi there, I had the same problem. The error message was:

DOE-2 Simulation DLL Error.

Unable to load library C:\Program Files (x86)\eQuest 3-65-7175\DOESimR.dll failed with error 8: Not enough memory resources are available to process this command.

One doesn't expect modern software to have memory issues, but I wonder if it may actually be something to do with memory. Although clearly my machine has plenty of RAM, this thread suggests that some other (but not all) 32-bit programs have encountered similar problems (eQuest is 32-bit). If my task manager shows that I am using more than about 4.5 GB of RAM (or about 2.3 GB per slot), then I have this error. If I close out other programs and try again, success! At least that has worked a couple times for me.