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Hi Shanta,
Good to hear from you. We use DaySim / Radiance for daylighting, and ASHRAE RTS method (with enhancements for accuracy of solar gains) for load calcs. We have integrated EnergyPlus for thermal comfort calculations, and will soon be launching deeper integration with Open Studio and EnergyPlus for MEP system design, sizing, & planning. While we have over 300 architecture firms using Sefaira, we now have some MEP firms piloting our new solution for MEP system design as well.
We have done validation studies along the lines of 140, and are happy to share that documentation. If you are interested in taking a look, just send me a note or provide me an email address. I will get in touch with you.