Question-and-Answer Resource for the Building Energy Modeling Community
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It depends on what end uses you are seeing that differ significantly between the hourly and monthly results. For an hourly simulation, I'd start with schedules of operation and weather data. Once you have base loads calibrated (i.e. lighting and equipment) you can get a better idea of what other variables that these influence (i.e. heating and cooling) are off and by how much.
There are a lot of resources and guidance on how to approach model calibration, and there are some Q&A on this site on cloud simulation using OpenStudio that may be useful. Here is a paper on it as well: https://www.nrel.gov/docs/fy14osti/61420.pdf
From that paper, here are some common adjustments for model calibration:
