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From an E+ perspective, the setpoint manager (SPM) configuration you tried sounds correct. For an AirLoop with a single setpoint, the typical approach is to define a single setpoint after the fan, and then use SetpointManager:MixedAir SPMs on the nodes upstream of the fan to propagate the setpoint (adjusted for fan heat) to these nodes.

My best guess is that DesignBuilder is automatically putting SetpointManager:MixedAir SPMs on the nodes of upstream of the fan, and that these auto-generated SPMs are overriding the 54F SPM you put on the campus CHW coil outlet node.

Here's what I'd do:

  1. Request and plot the System Node Setpoint Temperature output for the campus CHW coil outlet node. If you see that the setpoint is slightly less than 43F (to account for fan heat), you'll know that your 54F SPM is being ignored, and that it is likely due to a SetpointManager:MixedAir.
  2. In the IDF, check if there is a SetpointManager:MixedAir assigned to the outlet node of the campus CHW coil.

If my guess is correct, the solution would be to remove the SetpointManager:MixedAir from the outlet node of the campus CHW coil. No idea how this is done with DesignBuilder, but they have a Help Desk on the DB website under the Support options.