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This might be a good place to start.

http://pythonhosted.org//eppy/index.html#

OpenStudio also has Python bindings, and works at a higher level of abstraction.

This might be a A good place to start.

http://pythonhosted.org//eppy/index.html#start might be Eppy.

OpenStudio also has Python bindings, and works at a higher level of abstraction.

A good place to start might be Eppy. There's a good high-level introduction to what Eppy is and can do on Github.

Also, something the author, Santosh Philip said in a release email (April 2014) about Eppy's background:

"Eppy was developed over the last year, for the ASHRAE 1651-RP research project that required modifying large number of files and analyzing the results.

Eppy was partially funded by ASHRAE and the original code was written in 2004 as a text interface for Energyplus and the scripting language was built on it's foundations."

The open source license was GPLv3, but as of v0.5.0 it is MIT.

OpenStudio also has Python bindings, and works at a higher level of abstraction.