Question-and-Answer Resource for the Building Energy Modeling Community
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The is a lot of literature on this, for EnergyPlus the best places to start are
You might also check COMIS Fundamentals (LBL-28560) here or CONTAM's documentation (NIST-TN-1887) here. The EnergyPlus pressure network implementation is similar to what is in COMIS and CONTAM, so it may provide some context.
As for what reference conditions to use, for effective leakage area you can convert from one set to another as long as you are careful. The role that the conditions play is described in the ASHRAE Handbook of Fundamentals chapter, see equation 41 and the surrounding discussion (in the 2013 edition). The exact values are probably less important than making sure that the overall airtightness of your model is representative of the type of building that you are modeling. There is residential data on that in the Handbook of Fundamentals chapter and a database of residential airtightness maintained by Berkeley Lab here.
