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I'd suggest using the parametric capability of OpenStudio Server. You could write a measure to apply your schedule changes to the models and then run the analysis on Amazon EC2. All the graphical analysis capabilities of OS-Server would be available for you to analyze your results (parallel coordinate plot, scatter plots, etc) as the model results get stored in a mongo database. You can also download a csv or R dataframe of the entire results to do custom plots or analysis offline.

A user guide for OS-server lives here. There are also several examples in the github repo.

This approach will also work on existing E+ models using E+ measures, so having a seed OpenStudio model is not necessary (you just wont get access to the model userscript functionality of OS).