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Yes, you can do VRP with OpenStudio. Ostensibly the engineers who designed the systems also did these calculations, and therefore your modeled results should match the mechanical schedule. However, differences between their assumptions about space type, design occupancy, and zone air distribution effectiveness could lead to differences in results. Given these caveats, here's how to do it in OS:

1. Make sure your spaces have DesignSpecification:OutdoorAir objects setup with the correct per-area and per-person values. The OpenStudio templates have these setup already.
2. Click on the dashed line in the middle of your AirLoop
3. In the Inspector (right column), scroll down to Sizing:System and set the "System Outdoor Air Method" to "VentilationRateProcedure"
4. After you run the simulation, open the EnergyPlus Results file. There will be a 62.1 section that breaks down the values used in the VRP calculation, which you can double-check.

For more info on how E+ implements VRP, read this section in the engineering reference.