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For a crude way to do it, schedule your infiltration object.

For example, you can use a SpaceInfiltrationDesignFlowRate object (ZoneInfiltration:DesignFlowRate in E+), with an Air changes per hour value of P (=peak flow, say 6 ACH), and a schedule: set it to 1 when the doors are open, and for eg 0.1 (=0.6 ACH) for the rest of time.

Since you say it's one minute at a time, it's probably best to calculate average ACHs and enter a schedule with less granularity, but that depends on the goal of your analysis.