According to Help Reference-Getting started, "The general rule is to use the number of fan systems (and radiant systems) not the number of rooms to determine the number of zones in the building. ". The case i have at hand is one simple building with 10 stories and i am going to assign 10 thermal zones and one single thermal zone for it, respectively and make comparison in terms of total energy consumption of assigned VRF hvac system. However, when i run simulations in Energyplus, the energy consumption of HVAC system under two situations differ greatly. It is out of my expectations because the Reference said "the total building load calculated using a one-zone model of the Education Center (Figure 5.2) will NOT be significantly different from the total building load calculated using a more detailed model." The simulation results are pasted below for two situations. If the building is separated into 10 thermal zones: Heating: 0 Cooling:836.85 Interior Lighting:12411.44 Interior Equipment:13053.06 Fans:31.40 if the building is modeled by only one thermal zone: Heating: 42.59 Cooling:1530.88 Interior Lighting:12411.44 Interior Equipment:13053.06 Fans: 75.80