Can Eppy be used to modify the IDF mid-simulation?

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I've been looking into using Eppy to run EnergyPlus simulations using Python and it seems to be a great way to do that! I see Eppy can be used to make modifications to the IDF, but I'm a uncertain on whether or not modifications can be made to the IDF mid-simulation. This would be helpful for applications such as opening a window at a particular timestep.