@rraustad There appears to be a difference. I modeled a stratified air source water heater in OpenStudio. Both source (the heat pump) and use (Plant Water Loop) were connected to the same two nodes (Use Side Inlet and Outlet Nodes). This left the Source Side nodes unused with the result:
** Severe ** InitWaterThermalTank: Detected problem for stratified tank model. Model cannot be applied.
** ~~~ ** Occurs for stratified tank name = HPWH TANK
** ~~~ ** Tank volume = 0.1893 [m3]
** ~~~ ** Tank use side volume flow rate = 4.7685E-003 [m3/s]
** ~~~ ** Tank source side volume flow rate = -99999.0000 [m3/s]
** ~~~ ** Nominal tank change over rate = 39.70 [s]
** ~~~ ** Change over rate is too fast, increase tank volume, decrease connection flow rates or use mixed tank model
** Fatal ** InitWaterThermalTank: Simulation halted because of sizing problem in stratified tank model.