How to control EnergyPlus parameters for each timestep using Python?

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Instead of using eppy, I would recommend using an EnergyPlus feature - Energy Management Systems (EMS). This replicates a Building Automation System, which at its core is a combination of:

• sensors to measure EnergyPlus outputs (PUE, DEC temperature)
• actuators to override standard EnergyPlus behavior (the inputs you want to set directly)
• programs to define the logic and calculations for how sensors and actuators work together

Each EMS component can use updated information from EnergyPlus at each timestep. There are many posts on Unmet Hours regarding how to use EMS, if you search for EnergyPlus EMS in the Search or ask your question bar at the top of the page or look at posts using the ems question tag.