Question-and-Answer Resource for the Building Energy Modeling Community
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You can also explore the use of multipliers. It often cuts down time without compromising any results.
Regarding the runtime of about 3.5 hours, DesignBuilder often divides the runtime into actual runtime and postprocessing of the results. If you could see the actual energyplus runtime less than the results processing, this would also help you troubleshoot your model and optimize runtime parameters by removing some unused output parameters.
