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Hi, this is widely documented in the energyplus documentation. To start you can refer to the "Running energyplus as a library" page: https://bigladdersoftware.com/epx/docs/22-1/input-output-reference/api-usage.html

The python API has also a documentation website with all the available functions. https://nrel.github.io/EnergyPlus/api/python/

For your case, you can specifically find if the setting you want to change is listed as an actuator in the first website I listed. Actuators can overwrite a value during simulation time.