Question-and-Answer Resource for the Building Energy Modeling Community
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OpenStudio's Large Scale Analysis Workflow may be ideal for this. You could write a measure to alter the setback times and or values (we already have some like this), and then use feedback loop from simulation results to find the optimal solution based on annual consumption. Of course it sounds like you may want to dynamic setbacks that adapt to conditions vs. a more typical schedule. That would take another thought.
If you take formula approach, as described in your link, where you find optimal solution based on buildings thermal inertia and outside conditions, you could do a short simulation run within a measure to evaluate the thermal Inertia and to get access to the annual weather data. Then you could either write out custom schedules (since you know what the weather will be like) or I expect could write EMS code to control the system dynamically.
