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Jupil you are probably speaking about a Demand Controlled Ventilation (DCV) which operates the fan following the room CO2 concentration ? You can modify the contaminant setpoint (here CO2) in DesignBuilder or EnergyPlus, or do a parametric study with GenOpt or jEPlus like quoted above. If you need any example in EnergyPlus look for files with "DCV" in the Example folder.