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Hello, based on my understanding of energy modeling, eQuest included, infiltration is an input, not a calculated output. Therefore, you use the built-in infiltration models to specify how you want infiltration "modeled". No matter the balance of air in the building/zone, infiltration remains as you input it. There will be no change because you have exhausted an extra 50 cfm of air. The infiltration you input will impact the thermal loads only, not the balance of air. Balance of air is done by the user.

To overcome, you may use a method developed at NIST (Ng et al.). It takes into account building characteristics, central system flow (including exhaust), and weather. The report can be found here http://dx.doi.org/10.6028/NIST.TN.1829. You can also find the method in the ASHRAE Journal July 2014 Issue.

Good luck and let me know if you have further questions.