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Are you looking to actually run the simulations on your Mac or do you just want a Mac client to run simulations elsewhere, e.g., on the cloud?
Either way, JEPlus will do this. And it's a Java application so it will run on Macs or pretty much anything else (Raspberry Pi?). You could try OpenStudio, specifically the new Analysis Framework which is spreadsheet driven and will run things locally or on EC2. OpenStudio has the advantage of supporting "higher-order" measures in addition to simpler parametrics like weather files. Another option is the new web-based framework Apidae (apidaelabs.net).
I am not sure what else is available for Macs. There are probably more web-based options. Perhaps others will chime in.