Question-and-Answer Resource for the Building Energy Modeling Community
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I think you are going to get different answers here from different people, but you seem to be asking a plant/system optimization question without providing details on the plant and system itself: what is your cooling source? Heating source? Pump sizing and configuration? What kind of fan do you have? What are your equipment curves?
I think you've asked a question with an open-ended answer because these will each be different based on your building dynamics - you may not have the same answer building to building or even for the same building with a different plant/system. But, that is why simulating them as you've done is important.
In an attempt to answer your question - you might use flow first where your flow curves are more efficient (i.e., fans) and you might use temperature first where your plant curves are more efficient (i.e., pumps).
