Question-and-Answer Resource for the Building Energy Modeling Community
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You might consider something like DesignBuilder's Optimization tools which use genetic algorithms and EnergyPlus to undertake advanced multi-criteria cost-benefit analysis. Other tools are available but this is probably the easiest/quickest to set up and use. You can set up a range of different envelope options (also shading, HVAC, lighting etc) and then the optimiser manages the process of running multiple simulations to find the solutions that best meet your objectives (cost, performance etc.). You can find information about this on the DesignBuilder website or a webinar recording on DesignBuilder's YouTube channel or contact the office directly.
