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Not an answer to your primary question, but CBECC-Com has the OpenStudio SDK (not the graphical part) and EnergyPlus inside it. So in some sense you are using OpenStudio and EnergyPlus for this particular calculation whichever interface you use. Given that, it seems--for this application at least--the choice is a matter of preference. If you are already using IES-VE and like it ...
In other matters, the OpenStudio scripting facility you've heard about is called Measures. It's a generic facility that has access to the OpenStudio API and can be used to transform and query models, query and process simulation results, and implement general workflow automation. The name Measures comes from the fact that initial uses were implementation of transformations that correspond to ECMs (Energy Conservation Measures). Measures are written in Ruby, not Python. Close enough. If ever there was a reason for you to switch to OpenStudio, Measures would be it. But, again, it sounds like your current setup is working for you.