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DOE2 runs fast. Therefore, I can quickly explore the impact of changes to my model and perform some old-fashioned human-driven optimization. And the ability to make quick incremental changes and check the results also helps me to avoid errors and produce better quality models.
I find that when I use slower simulation tools that I have to work differently and I'm more reluctant to test things. It requires more planning ahead, running batches, etc. That's not necessarily a bad thing. It's just different and tests my patience!