Question-and-Answer Resource for the Building Energy Modeling Community
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If you can quantify the process loads and the heat gains to the zones, then it should be possible. EnergyPlus has internal gains objects for Electric, Gas, and "Other" (heat/cool source with no utility consumption). If you want to model the boiler and chiller loads from the industrial equipment, the LoadProfile:Plant object can place a scheduled hot water or chilled water load on the plant. So, it is possible, depending on the complexity and what you expect to get from the model.
